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. 2023 Apr 25;24(9):7830. doi: 10.3390/ijms24097830

Figure 4.

Figure 4

Effects of treadmill exercise on cognition dysfunction in MPTP-induced chronic PD model. (A) An example ethogram of single-mouse locomotion features and trajectories. The blue dot is the starting position and the red dot is the ending position. (B) Time spent in target quadrant (%) (F(2,33) = 58.91, p < 0.001), (C) platform-cross frequency (F(2,33) = 22.66, p < 0.001) (D) path length, (E) and time spent searching for platform over 5 days with respect to mice performing the Morris water maze test (n = 12). (F) Schematic diagram of novel object recognition test, (G) percentage of time spent with the novel object to total object exploration time (F(2,21) = 70.40, p < 0.001), (H) and the total object exploration time (F(2,21) = 39.01, p < 0.001) of mice in NOR (n = 8). Data represent the mean ± SEM *** p < 0.001 vs. control, ### p < 0.001 vs. MPTP group.