Skip to main content
. 2023 Apr 24;24(9):7775. doi: 10.3390/ijms24097775

Figure 2.

Figure 2

ENaC subunit cysteines (mouse ENaC). (A) A Schematic of an ENaC subunit, adapted from [5]. Cysteine residues are represented by yellow circles, and disulfide bonds observed in the ASIC1 structure are represented by black bars. Conserved aspartic acids αAsp-171 and γAsp-115 are represented by a red circle, and αTyr-474 is represented by a blue circle. (B) B Sequence alignment of finger domain segment hosting conserved cysteines in ENaC subunits. (C) C Sequence alignment of the thumb domain residues proximal to the finger domain in the ASIC1 structure. Identities are shaded gray. Cysteines are shaded black. Reproduced from [83] (Figure 1); Copyright © 2023 by The American Society for Biochemistry and Molecular Biology, Inc.; published by American Society for Biochemistry and Molecular Biology, Baltimore, MD, USA.