Figure 1.

Histological photomicrographs and quantitative analysis of NASH parameters. APOE*3-Leiden mice were fed a Western-type diet (WTD) with (n = 16) or without (n = 16) atorvastatin admix for 32 weeks. Chow-fed mice (n = 10) were included as a healthy reference. Representative histological photomicrographs of H&E-stained and Sirius Red-stained liver cross-sections (A). Total steatosis (B) and hepatocellular hypertrophy (C) as percentage of surface area, number of inflammatory foci per mm² microscopic field (D), fibrosis as percentage of surface area (E) and fibrosis stage (F0–F4) (F) were determined at the study endpoint (t = 32 weeks) and are presented as mean ± SEM. ** p < 0.01, *** p < 0.001 vs. WTD. ## p < 0.01, ### p < 0.001 vs. chow.