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. 2023 Apr 25;24(9):7818. doi: 10.3390/ijms24097818

Figure 3.

Figure 3

Atorvastatin ameliorates inflammatory cell infiltration and NLRP3 inflammasome activation in the liver. APOE*3-Leiden mice were fed a Western-type diet (WTD) with (n = 16) or without (n = 16) atorvastatin admix for 32 weeks. Chow-fed mice (n = 10) were included as a healthy reference. Histological photomicrographs of liver cross-sections stained for CD68, myeloperoxidase (MPO) Ly6C/G and NLRP3 (A). Liver CD68, MPO, Ly6C/G and NLRP3 content as measured by percent positive area and expressed as a fold-change relative to chow (B–E, respectively) and hepatic protein levels of IL-1β (F) and IL-18 (G) measured by ELISA at the study endpoint (t = 32 weeks). Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. WTD. ### p < 0.001 vs. chow.