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. 2023 Apr 27;24(9):7962. doi: 10.3390/ijms24097962

Table 7.

Essential oils showing no appetite-related effects in animal models.

No. Essential Oil Major Compounds Route of Administration Dose Duration Species Mechanism References
1 Ocimum sanctum L. essential oil Eugenol
Methyl eugenol
Mix with diet 80 µL/kg bw/day 3 weeks Wistar rats n/a [43]
2 Hyptis martiusii Benth. essential oil 1,8-Cineole
δ-3-Carene
Oral 100, 500 mg/kg 30 days Swiss mice n/a [47]
3 Citronella essential oil R-Citronellal
Neryl acetate
Inhalation 100× dilution in water Sprague Dawley rats n/a [48]
4 Minthostachys verticillata essential oil Pulegone
Menthone
Mix with diet 1, 4, 7 g/kg feed 90 days Wistar rats n/a [49]
5 Satureja khuzistanica essential oil Carvacrol
p-Cymene
Mix with water 200, 300, 400, and 500 mg/L in water 42 days Arian broiler chicks n/a [50]
6 Aquilaria crassna essential oil n/a Oral 100, 500 mg/kg 28 days Swiss mice n/a [51]
7 Ginger essential oil Geranial
Neral
Inhalation 4.5 × 10−4 mg/cage 1h ddY mice n/a [53]
8 Geranium essential oil n/a Inhalation 4.5 × 10−3 mg/cage 1h ddY mice n/a [54]
9 Pennyroyal essential oil Pulegone
3,3′-dimenthol
Mix with diet 200, 300, and 400 ppm 35 days Japanese quail n/a [59]
10 Savory essential oil Thymol
4,4′-diapophytoene
Mix with diet 200, 300, and 400 ppm 35 days Japanese quail n/a [59]
11 Lavender essential oil Linalool
1,8-Cineole (Eucalyptol)
Camphor
Oral 2000 mg/kg 21 days Swiss albino mice n/a [64]
12 Eupatorium buniifolium essential oil α-pinene
(E)-β-guaiene
Oral 300, 3000, 6000 ppm 12 days Apis mellifera bees n/a [68]
13 Carvacrol essential oil from Lippia graveolens Carvacrol
p-Cymene
Mix with diet 1% (w/w) of diet 9~12 days Apis mellifera bees n/a [70]
14 Sesquiterpenes essential oil from Lippia graveolens β-Caryophyllene
α-Humulene
Mix with diet 1% (w/w) of diet 9~12 days Apis mellifera bees n/a [70]
15 Thymol essential oil from Lippia graveolens Thymol
β-Caryophyllene
Mix with diet 1% (w/w) of diet 9~12 days Apis mellifera bees n/a [70]
16 Lavender essential oil Linalool
1,8-Cineole (Eucalyptol)
Camphor
Mix with diet 250 mg/kg diet 14 weeks Lohmann LSL-Lite laying hens n/a [73]
17 Mentha spicata essential oil Carvone
Limonene
Mix with diet 250 mg/kg diet 14 weeks Lohmann LSL-Lite laying hens n/a [73]
18 Linalool essential oil from Thymus vulgaris Linalool
Carvacrol
Mixed in aquarium 100 mg/L n/a Colossoma macropomum n/a [75]
19 Thymol essential oil from Thymus vulgaris Thymol
p-Cymene
Mixed in aquarium 50 mg/L n/a Colossoma macropomum n/a [75]

bw: body weight; n/a: not applicable.