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. 2023 May 15;133(10):e153837. doi: 10.1172/JCI153837

Figure 4. Normalization of membrane permeability with EDG-5506 in mdx mice without detrimental effects on strength and coordination in vivo.

Figure 4

(A) Left: Rotarod performance. Right: Forelimb grip strength 4 hours after oral administration of EDG-5506 (n = 10–31). (B) Plasma CK activity from blood taken 1 hour after rotarod (left) or grip strength tests (right) (n = 10–19). (C) Representative whole-body images of nonexercised mdx mice 24 hours after intravenous administration of Evans blue dye. Mice were treated for 3 weeks with vehicle or EDG-5506 (these images were reproduced as part of Supplemental Figure 4C). (D) Quantitation of Evans blue dye–positive area in the hind limbs of treated mice (n = 5) (1–10 mg/kg represents approximately 0.079–0.79 μmol EDG-5506/mouse). Significance was calculated by 1-way ANOVA with Dunnett’s multiple-comparison test. *P < 0.05; ***P < 0.001; ****P < 0.0001.