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. 2023 May 15;133(10):e153837. doi: 10.1172/JCI153837

Figure 6. Selective inhibition of active contraction in fast skeletal muscle decreases CK and increases habitual activity in DMD dogs.

Figure 6

(A) Plasma CK activity in 7-month-old DMD dogs (n = 4) before, during, and after 14 days oral gavage with EDG-5506. Each data point represents CK activity from an individual blood draw (2–3 draws during the vehicle baseline, 5–8 draws during the dosing period, and 2 draws during the vehicle washout). In a separate study, the same 4 dogs were dosed daily with vehicle, and blood CK was at regular intervals for 14 days (indicated as vehicle repeat, 6–9 blood draws per dog). Data are shown as the mean ± SEM. (B) Average daily activity measures from an electronic activity monitor (FitBark) in the same DMD dogs (n = 3, 15 months old) before, during, and after an 11-day oral gavage with EDG-5506 (2 mg/kg daily for 4 days, then every other day). Each data point represents the daily average activity for the 3 dogs. (C) Timed function data from the same activity monitors. Average daily active time, average daily play time, and average daily rest time. Each point represents average activity for 1 day (2 mg/kg represents approximately 68.2 μmol EDG-5506/dog). Significance was calculated by 1-way ANOVA with Tukey’s multiple-comparison correction. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.