Table 2.

Assessment of interleukin targets and their clinical correlations when treating pain and inflammation associated with nervous system diseases.

Clinical Drugs	Target Interleukin	Site of Action	Disease Model
Canakinumab	IL-1β	Periphery, brain, spine	Knock-out mice, peripheral nerve injury
Tocilizumab	IL-6	Periphery, spine	CCI, peripheral nerve injury, knock-out mice
Secukinumab	IL-17	Periphery	Peripheral nerve injury, chemical injection, knock-out mice, arthritis
Glatiramer	IL-4	Periphery	CCI, partial nerve injury
Calcineurin	IL-10	Periphery, brain	Partial/complete nerve injury, neuritis