Table 1.

Levels of Evidence for Therapeutic Studies (From the Centre for Evidence-Based Medicine, http://www.cebm.net (accessed on 15 February 2023)).

Level	Type of Evidence
1A	Systematic review (with homogeneity) and meta-analysis of randomized controlled trials (RCTs)
1B	Individual RCT (with narrow confidence intervals)
1C	All or none study
2A	Systematic review (with homogeneity) of cohort studies
2B	Individual Cohort study (including low-quality RCT, e.g., <80% follow-up)
2C	“Outcomes” research; Ecological studies
3A	Systematic review (with homogeneity) of case-control studies
3B	Individual Case-control study
4	Case series (and poor-quality cohort and case-control study
5	Expert opinion without explicit critical appraisal or based on physiology bench research or “first principles”.