Table 3.

Molecular docking data.

Target	ΔG (kcal/mol)	Full Fitness (kcal/mol)	Energy	H-Binding Residue/ H-Bonding Distance
Vismione E
IMPDH2	−7.478466	−5339.8955	7.369	Lys229 H …O 2.165 Å
	−7.4588733	−5338.026	18.4965	Lys489 HN … O 2.678 Å H …O Glu487 3.265 Å
MMP1	−6.889332	−4766.2676	29.1129	H…O Gln974 2.119 Å
ADAM17	−7.782852	−3054.5269	12.3965	Lys455 H … O 3.173 Å Ala266 HN … O 2.051 Å H … O Ala270 2.679 Å Lys273 H … O 2.302 Å
CDK8CCNC	−7.634472	−3557.7717	15.7452	Lys18 H…O 2.056 Å
Mycophenolic acid
IMPDH2	−7.7401905	−5380.3955	1.44649	Lys489 HN … O 2.830 Å Asp16 HN … O 2.136 Å H …O Pro14 1.805 Å
Theoretical de-prenylated derivative of vismione E
IMPDH2	−6.7235613	−5343.706	22.4293	Lys489 HN … O 2.269 Å
	−6.6762652	−5344.5107	18.8873	H …O Asp15 2.911 Å