Table A2.
The top 50 predicted molecular targets of vismione E based on SwissTargetPrediction.
| Target | Common Name | Uniprot ID | ChEMBL ID | Probability |
|---|---|---|---|---|
| Inosine-5′-monophosphate dehydrogenase 2 | IMPDH2 | P12268 | CHEMBL2002 | 0.109339753231 |
| Matrix metalloproteinase 1 | MMP1 | P03956 | CHEMBL332 | 0.109339753231 |
| ADAM17 | ADAM17 | P78536 | CHEMBL3706 | 0.109339753231 |
| CDK8/Cyclin C | CCNC CDK8 |
P24863 P49336 |
CHEMBL3038474 | 0.109339753231 |
| Cell division protein kinase 8 | CDK8 | P49336 | CHEMBL5719 | 0.109339753231 |
| PI3-kinase p110- alpha subunit | PIK3CA | P42336 | CHEMBL4005 | 0.109339753231 |
| Proto-oncogene tyrosine-protein kinase ROS | ROS1 | P08922 | CHEMBL5568 | 0.109339753231 |
| Interleukin-8 receptor B | CXCR2 | P25025 | CHEMBL2434 | 0.109339753231 |
| Tyrosine-protein kinase SYK | SYK | P43405 | CHEMBL2599 | 0.109339753231 |
| Leucine-rich repeat serine/threonineprotein kinase 2 | LRRK2 | Q5S007 | CHEMBL1075104 | 0.109339753231 |
| Cyclin-dependent kinase 1/cyclin B | CCNB3 CDK1 CCNB1 CCNB2 | Q8WWL7 P06493 P14635 O95067 | CHEMBL2094127 | 0.109339753231 |
| Mammalian target of rapamycin (mTORC1) | FKBP1A MTOR | P62942 P42345 | CHEMBL2221341 | 0.109339753231 |
| Phosphodiesterase 5A | PDE5A | O76074 | CHEMBL1827 | 0.109339753231 |
| Matrix metalloproteinase 9 | MMP9 | P14780 | CHEMBL321 | 0.109339753231 |
| Interleukin-1 receptor-associated kinase 4 | IRAK4 | Q9NWZ3 | CHEMBL3778 | 0.109339753231 |
| Corticotropin releasing factor receptor 1 | CRHR1 | P34998 | CHEMBL1800 | 0.109339753231 |
| Matrix metalloproteinase 3 | MMP3 | P08254 | CHEMBL283 | 0.109339753231 |
| Thrombin and coagulation factor X | F10 | P00742 | CHEMBL244 | 0.109339753231 |
| Protein farnesyltransferase | FNTA FNTB | P49354 P49356 | CHEMBL2094108 | 0.109339753231 |
| Phosphodiesterase 2A | PDE2A | O00408 | CHEMBL2652 | 0.109339753231 |
| P2X purinoceptor 3 | P2RX3 | P56373 | CHEMBL2998 | 0.109339753231 |
| Macrophage colony stimulating factor receptor | CSF1R | P07333 | CHEMBL1844 | 0.109339753231 |
| Tyrosine-protein kinase JAK3 | JAK3 | P52333 | CHEMBL2148 | 0.109339753231 |
| Protein kinase C gamma | PRKCG | P05129 | CHEMBL2938 | 0.109339753231 |
| Protein kinase C delta | PRKCD | Q05655 | CHEMBL2996 | 0.109339753231 |
| Protein kinase C alpha | PRKCA | P17252 | CHEMBL299 | 0.109339753231 |
| Cyclin-dependent kinase 4/cyclin D1 | CCND1 CDK4 | P24385 P11802 | CHEMBL1907601 | 0.109339753231 |
| Cyclin-dependent kinase 2/cyclin E | CCNE2 CDK2 CCNE1 | O96020 P24941 P24864 | CHEMBL2094126 | 0.109339753231 |
| Casein kinase II alpha | CSNK2A1 | P68400 | CHEMBL3629 | 0.109339753231 |
| Cyclin-dependent kinase 2/cyclin A | CDK2 CCNA1 CCNA2 | P24941 P78396 P20248 | CHEMBL2094128 | 0.109339753231 |
| PI3-kinase p110- beta subunit | PIK3CB | P42338 | CHEMBL3145 | 0.109339753231 |
| Nerve growth factor receptor Trk-A | NTRK1 | P04629 | CHEMBL2815 | 0.109339753231 |
| p53-binding protein Mdm-2 | MDM2 | Q00987 | CHEMBL5023 | 0.109339753231 |
| Serine/threonineprotein kinase SMG1 | SMG1 | Q96Q15 | CHEMBL1795195 | 0.109339753231 |
| Tyrosine-protein kinase ABL | ABL1 | P00519 | CHEMBL1862 | 0.109339753231 |
| Proto-oncogene vav | VAV1 | P15498 | CHEMBL3259472 | 0.109339753231 |
| Phosphodiesterase 10A | PDE10A | Q9Y233 | CHEMBL4409 | 0.109339753231 |