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. 2023 May 7;24(9):8399. doi: 10.3390/ijms24098399

Table 5.

The most essential EMT-associated genes targeted by AR, ESR1, and ESR2 based on [28,29,69].

Gene Name Marker of
CDH1 Cadherin 1, E-cadherin Epithelial state
COL4A1 Collagen type IV α-1 chain
DSP Desmoplakin
KRT18 Keratin 18
KRT19 Keratin 19
KRT5 Keratin 5
LAMA1 Laminin subunit α-1
LAMA2 Laminin subunit α-2
LAMA3 Laminin subunit α-3
LAMA4 Laminin subunit α-4
LAMA5 Laminin subunit α-5
MUC1 Mucin 1
NID1 Nidogen 1
OCLN Occludin
TJP1 Tight junction protein 1
ACTA2 Actin 2, α 2 Mesenchymal state
CDH11 Cadherin 11
CDH2 Cadherin 2, N-cadherin
CTNNB1 Catenin β 1
DDR2 Discoidin domain receptor tyrosine kinase 2
FN1 Fibronectin 1
GSC Goosecoid homeobox
ITGA5 Integrin subunit α 5
ITGB6 Integrin subunit β 6
KRT8 Keratin 8
LEF1 Lymphoid enhancer binding factor 1
MMP2 Matrix metalloproteinase 2, Gelatinase A
MMP3 Matrix metalloproteinase 3, Stromelysin 1
MMP9 Matrix metalloproteinase 9, Gelatinase B
S100A4 S100 calcium binding protein A4
SDC1 Syndecan 1
SERPINH1 Serpin family H member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SNAI2 Snail family transcriptional repressor 2
TCF3 Transcription factor 3
TCF4 Transcription factor 4
TWIST1 Twist family bHLH transcription factor 1
VIM Vimentin
ZEB1 Zinc finger E-box binding homeobox 1
ZEB2 Zinc finger E-box binding homeobox 2