ASD	antiseizure drug
MES test	maximal electroshock seizure test
6 Hz test	6 Hertz test
scPTZ test	subcutaneous pentylenetetrazole test
ivPTZ test	intravenous pentylenetetrazole test
ADME-Tox	Absorption Distribution Metabolism Elimination and Toxicology
PILO	pilocarpine
PILO-induced SE	pilocarpine induced status epilepticus
DCC	(N,N′-dicyclohexylcarbodiimide)
TFA	trifluoroacetic acid
HMDS	hexamethyldisilazane
MW	molecular weight
Log P	lipholicity values
HBD	hydrogen bond donors
HBA	hydrogen bond acceptors
NBR	number of rotatable bonds
TPSA	topological polar surface area
LIPO	lipophilicity
POLAR	polarity
INSOLU	solubility
FLEX	flexibility
INSATU	saturation of the molecule
CNS	central nervous system
MPO	multiparameter optimization
GI	gastrointestinal
HIA	human intestinal absorption
BBB	blood-brain barrier
PGP+/−	poliglicoprotein
ED50	effective dose
TD50	Toxicity dose
SD	Standard Deviation
TI	Therapeutic Index
VPA	valproic acid
i.p.	intraperitoneal injection
GABAA	γ-aminobutyric acid A
AMPA	α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
NMDA	N-methyl-D-aspartic acid
hERG	human ether-à-go-go-related gene
TRPV1	Transient receptor potential vanilloid 1
VR1	Vanilloid type 1 receptor
5-HT1A	serotonin 1A
GAT-1	GABA transporter 1
SV2A	synaptic Vesicle Glycoprotein 2A
PAMPA	parallel artificial membrane permeability
HLMs	Human liver microsomes
CYP3A4	Cytochrome P450 3A4
CYP2D6	Cytochrome P450 2D6
HepG2	Hepatoblastoma cell line
SH-SY5Y	Human Neuroblastoma cell line