Table 2.
E3 Ubiquitin ligase in DNA damage.
| Name | Type | Substrate | Ubiquitination Residue | Ref. (PMID Number) |
|---|---|---|---|---|
| ARF-BP1/Mule | HECT | p53 | unknown | 15989956 |
| MCL-1 | unknown | 15989957 | ||
| E6-AP | HECT | p53 | unknown | 31749782 |
| HUWE1 | HECT | histone H1 | unknown | 29127375 |
| ITCH | HECT | p73 | unknown | 15678106 |
| p63 | unknown | 16908849 | ||
| WWOX | K63 | 25331887 | ||
| H1.2 | K48, K63 | 30517763 | ||
| NEDD4 | HECT | RNA PolⅡ | unknown | 17996703 |
| Mdm2 | K63 | 24413081 | ||
| NEDD4L | HECT | OGG1 | unknown | 33282879 |
| Rsp5 | HECT | RNA PolⅡ | unknown | 9108033 |
| Smurf1 | HECT | RhoB | unknown | 25249323 |
| Smurf2 | HECT | H2AX | unknown | 31533041 |
| RNF20 | unknown | 33097595 | ||
| TRIP12 | HECT | USP7/HAUSP | K48 | 27800609 |
| UBR5 | HECT | ATMIN | unknown | 25092319 |
| WWP2 | HECT | SOX2 | unknown | 25042802, 34193614 |
| APC/CCdc20 | multimeric RING | MCL-1 | unknown | 29987118 |
| BIM | unknown | 24871945 | ||
| APC/CCDH1 | multimeric RING | CtIP | unknown | 25349192 |
| E2F1 | K11 | 22580462 | ||
| BRCA1 | RING | CtIP | unknown | 16818604 |
| BRCA1-BARD1 | RING | histone H2A | mono | 33589814 |
| RNA PolⅡ | K6 | 15886201, 15905410 | ||
| CHFR | RING | PARP1 | K48, K63 | 23268447 |
| COP1 | RING | p53 | unknown | 16931761 |
| CRL4ADDB1 | RING | p53 | unknown | 17967871 |
| p73 | unknown | 23085759 | ||
| CRL4Cdt2 | RING | p21 | unknown | 18794347 |
| Cul4B | RING | p53 | K48 (no direct evidence) | 33524014 |
| HUWE1 | unknown | 25883150 | ||
| CUL4-DDB-ROC1 | RING | histone H3, H4 | unknown | 16678110 |
| FANCL | RING | FANCD2 | unknown | 17352736 |
| MARCH7 | RING | Mdm2 | K63 | 29295817 |
| Mdm2 | RING | p53 | K48 | 12507556 |
| p73 | unknown | 34716260 | ||
| Pirh2 | RING | p53 | K48 | 12654245 |
| CHK2 | unknown | 23449389 | ||
| p73 | K11, K29, K48, K63 | 21994467 | ||
| Rad5 | RING | PCNA | K63 | 18757916 |
| Rad6 | RING | PCNA | K63 | 12226657 |
| Rad18 | RING | PCNA | K63 | 19851286 |
| RFWD3-Mdm2 | RING | p53 | unknown | 20173098 |
| RNF2 | RING | H2AX | unknown | 21676867 |
| RNF8 | RING | MDC1 | K63 | 18006705, 31182912 |
| histone H1 | K63 | 29127375 | ||
| histone H2A, H2AX | K63 | 22980979 | ||
| JMJD2A | K48 | 22373579 | ||
| Ku80 | K48 | 22266820 | ||
| PCNA | unknown | 18948756 | ||
| NBS1 | unknown | 23115235 | ||
| RecQL4 | K6, K27, K29 | 33674555 | ||
| RNF19A | RING | BARD1 | K63 | 34789768 |
| RNF20/RNF40 | RING | histone H2B | unknown | 30692271 |
| RNF111 | RING | XPC | unknown | 23751493 |
| RNF168 | RING | histone H2A | K27, K63 | 25578731, 22980979 |
| JMJD2A | unknown | 22373579 | ||
| H2AX | unknown | 31533041 | ||
| SCFFBXW7 | RING | p53 | K48 | 31346036, 31337255 |
| p63 | unknown | 20571051 | ||
| XRCC4 | K63 | 26774286 | ||
| PLK1 | K48 | 24970797 | ||
| SOX9 | unknown | 27566146 | ||
| BLM | K48 | 26028025 | ||
| SCFSKP2 | RING | NBS1 | K63 | 22464731 |
| SCFβ-TrCP | RING | BIM | unknown | 19150432 |
| CDC25A | unknown | 14681206 | ||
| CLASPIN | unknown | 16885022 | ||
| SCFβ-TrCP1 | RING | Mdm2 | K48 | 33676897 |
| SCFβ-TrCP2 | RING | Mdm2 | K63 | 33676897 |
| TRIM17 | RING | MCL-1 | unknown | 22976837 |
| TRIM24 | RING | p53 | unknown | 24820418 |
| UHRF1 | RING | RIF1 | K63 | 26727879 |
| Peli1 | RING-like | NBS1 | K63 | 30952868 |
| PRP19 | U-box | RPA | K63 | 24332808 |