Table 3.
Chemical formula of selected compounds targeting the UPS.
| Target | Compounds | Chemical Formula |
|---|---|---|
| 20S Proteasome | Bortezomib | C19H25BN4O4 |
| Carfilzomib | C40H57N5O7 | |
| Oprozomib | C25H32N4O7S | |
| Ixazomib | C14H19BCl2N2O4 | |
| E1 enzyme | TAK-243 (MLN7243) | C19H20F3N5O5S2 |
| E2 enzyme | CC0651 | C20H21Cl2NO6 |
| NSC697923 | C11H9NO5S | |
| Leucettamol A | C30H52N2O2 | |
| Manadosterol A | C54H83Na5O21S5 | |
| Manadosterol B | C54H84Na4O18S4 | |
| E3 ligase | Nutlin-3a | C30H30Cl2N4O4 |
| KRT-232 (AMG 232) | C28H35Cl2NO5S | |
| Milademetan (DS-3032) | C30H34Cl2FN5O4 | |
| HDM201 | C26H24Cl2N6O4 | |
| ALRN-6924 | C95H140N20O23 | |
| GDC-0917 | C29H36N6O4S | |
| Debio1143 (Xevinapant) | C32H43N5O4 | |
| Apcin | C13H14Cl3N7O4 | |
| TAME | C14H22N4O4S | |
| Oridonin | C20H28O6 | |
| SZL-P1-41 | C24H24N2O3S | |
| Longikaurin A | C20H28O5 | |
| Curcumin | C21H20O6 | |
| Dioscin | C45H72O16 | |
| GS143 | C28H19FN2O4 | |
| Erioflorin | C19H24O6 | |
| Deubiquitinase (DUB) | IU1 | C18H21FN2O |
| IU1-47 | C19H23ClN2O | |
| WP1130 | C19H18BrN3O | |
| HBX 41,108 | C13H3ClN4O |