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. 2023 May 4;24(9):8210. doi: 10.3390/ijms24098210

Figure 2.

Figure 2

Effect of RGE on the estrous cycle and estrogen and ovarian histopathology. Effect of RGE on body weights of mice with POF (a); Effect of RGE on estrous cycle of mice with POF (b,c); The effect of RGE on the ovarian indexes of mice with POF(h,i); Effects of RGE on serum E2 (d) and FSH levels in mice (e); Effects of RGE on estrogen receptor expression (f,g); Histological examination of the ovary using H&E staining (100×) (j); yellow triangles represent atretic follicles, D-gal group, low-dose RGE, and high-dose RGE. Data are expressed as Mean ± SD (n = 15). * p < 0.05, ** p < 0.01 vs. normal group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. D-gal group.