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. 2023 May 5;24(9):8322. doi: 10.3390/ijms24098322

Figure 2.

Figure 2

The effect of HFD feeding, oral P. gingivalis (Pg) inoculation, and imipramine treatment on the metabolic parameters and hepatic injury, including body weight (A), fasting glucose (B), insulin (C) and insulin resistance (HOMA-IR) (D), cholesterol (E), triglyceride (F), free fatty acid (G), and ALT (H) in mice. Six-week-old male C57BL/6 mice were fed HFD for 20 weeks to induce MetS and MetS-associated NAFLD and inoculated orally with Pg in the 15th week to induce periodontitis. Part of the mice were also treated with imipramine in the last eight weeks. Control mice were fed LFD and inoculated orally with a vehicle of Pg. At the end of the feeding and treatments, blood was collected, and the serum levels of the metabolic parameters were quantified. The data are mean ± SD (n = 12).