Table 1.

The Bone Volume Fraction (BVF) of Mice with or without P. gingivalis Inoculation, Metabolic Syndrome (MetS) and Imipramine Treatment.

	Mice Without Imipramine Treatment		Mice with Imipramine Treatment
	BVF	% BVF Change Compared to Control Mice	BVF	% BVF Change Compared to Mice without Imipramine Treatment
Control (LFD-fed)	0.663 ± 0.010	−	0.676 ± 0.009	+1.96%
P. gingivalis inoculation	0.626 ± 0.009	−5.58% *	0.679 ± 0.007	+8.47% **
MetS (HFD-fed)	0.624 ± 0.009	−5.88% **	0.621 ± 0.010	−0.48%
MetS + P. gingivalis inoculation	0.587 ± 0.008	−11.46% **	0.631 ± 0.008	+7.50% **

The BVF was quantified as described in Materials and Methods. In mice without imipramine treatment, the BVF for mice treated with P. gingivalis inoculation and/or HFD was compared with that for control mice (LFD-fed alone). In mice with imipramine treatment, the BVF in each group was compared with that in mice without imipramine treatment. * p < 0.05; ** p < 0.01.