Table 2.
Univariate and multivariate Cox analysis of OBC characteristics.
| Univariate Cox Analysis | Multivariate Cox Analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OS | BCSS | OS | BCSS | |||||||||
| HR | 95%CI | p Value | HR | 95%CI | p Value | HR | 95%CI | p Value | HR | 95%CI | p Value | |
| Age at dignosis | ||||||||||||
| <50 | reference | reference | reference | reference | ||||||||
| 50–59 | 1.338 | 0.9089–1.970 | 0.14 | 1.439 | 0.9340–2.216 | 0.099 | 0.79 | 0.4593–1.3585 | 0.39 | 0.7589 | 0.4224–1.3634 | 0.36 |
| 60–69 | 1.744 | 1.1980–2.538 | ** | 1.474 | 0.9554–2.275 | 0.079 | 1.1716 | 0.6870–1.9979 | 0.56 | 0.9772 | 0.5434–1.7572 | 0.94 |
| 70–79 | 2.195 | 1.4956–3.221 | *** | 2.015 | 1.2990–3.125 | ** | 1.3483 | 0.7734–2.3508 | 0.29 | 1.2467 | 0.6879–2.2593 | 0.47 |
| 80+ | 4.59 | 3.0608–6.882 | *** | 3.645 | 2.2560–5.888 | *** | 2.1283 | 1.0377–4.3651 | * | 1.5213 | 0.7263–3.1868 | 0.27 |
| Months from diagnosis to therapy | ||||||||||||
| 0 month | reference | reference | / | / | / | / | / | / | ||||
| ≥1 month | 1.085 | 0.8694–1.353 | 0.47 | 1.075 | 0.8335–1.388 | 0.57 | / | / | / | / | / | / |
| Subtypes | ||||||||||||
| HR+/HER2− | reference | reference | reference | reference | ||||||||
| HR+/HER2+ | 0.5526 | 0.3583–0.8523 | ** | 0.6496 | 0.4018–1.050 | 0.078 | 0.8763 | 0.5335–1.4395 | 0.60 | 1.0001 | 0.5760–1.7363 | 1.0 |
| HR−/HER2+ | 0.8551 | 0.5586–1.3088 | 0.47 | 0.9111 | 0.5578–1.488 | 0.71 | 0.8652 | 0.4985–1.5016 | 0.61 | 0.9611 | 0.5259–1.7564 | 0.90 |
| HR−/HER2− | 1.1147 | 0.8188–1.5177 | 0.49 | 1.2257 | 0.8594–1.748 | 0.26 | 1.9999 | 1.3739–2.9111 | *** | 2.6362 | 1.7191- 4.0426 | *** |
| Race | ||||||||||||
| white | reference | reference | / | / | / | / | / | / | ||||
| black | 0.8584 | 0.6055–1.217 | 0.39 | 0.738 | 0.4767–1.143 | 0.17 | / | / | / | / | / | / |
| other | 0.8479 | 0.5642–1.274 | 0.43 | 0.8337 | 0.5161–1.347 | 0.46 | / | / | / | / | / | / |
| Histological type | ||||||||||||
| IDC | reference | reference | reference | reference | ||||||||
| ILC | 2.951 | 2.036–4.276 | *** | 3.267 | 2.178–4.899 | *** | 1.5221 | 0.8794–2.6345 | 0.13 | 2.0359 | 1.1437–3.6242 | * |
| other | 1.875 | 1.434–2.452 | *** | 1.586 | 1.167–2.156 | ** | 0.8826 | 0.6165–1.2634 | 0.49 | 0.7979 | 0.5335–1.1933 | 0.27 |
| Marriage status | ||||||||||||
| married | reference | reference | reference | / | / | / | ||||||
| divorced/separated/other | 1.191 | 0.8917–1.591 | 0.24 | 1.105 | 0.7873–1.551 | 0.56 | 1.1943 | 0.8067–1.7680 | 0.38 | / | / | / |
| single | 1.272 | 0.9457–1.711 | 0.11 | 1.126 | 0.7898–1.605 | 0.51 | 1.0995 | 0.7145–1.6920 | 0.67 | / | / | / |
| widowed | 1.522 | 1.1612–1.996 | ** | 1.281 | 0.9222–1.779 | 0.14 | 0.7685 | 0.4741–1.2456 | 0.67 | / | / | / |
| widowed/divorced/other | ||||||||||||
| N Stage | ||||||||||||
| N0 | reference | reference | reference | reference | ||||||||
| N1 | 0.3618 | 0.28350–0.4616 | *** | 0.3474 | 0.26222–0.4604 | *** | 0.6602 | 0.4568–0.9542 | * | 0.5671 | 0.3734–0.8612 | ** |
| N2 | 0.1695 | 0.09877–0.2907 | *** | 0.1321 | 0.06642–0.2628 | *** | 0.4716 | 0.2351–0.9464 | * | 0.3411 | 0.1456–0.7991 | * |
| N3 | 0.3757 | 0.25815–0.5468 | *** | 0.4095 | 0.27027–0.6206 | *** | 0.9892 | 0.6176–1.5844 | 0.96 | 1.0411 | 0.6160–1.7595 | 0.88 |
| Grade | ||||||||||||
| well differentiated | reference | reference | / | / | / | / | / | / | ||||
| moderately differentiated | 2.73 | 0.3518–21.18 | 0.34 | / | / | / | / | / | / | / | / | / |
| poorly differentiated | 2.271 | 0.3118–16.54 | 0.42 | / | / | / | / | / | / | / | / | / |
| Median household income (inflation ajusted) | ||||||||||||
| <45,000$ | reference | reference | / | / | / | / | / | / | ||||
| 45,000–54,999$ | 0.9608 | 0.6266–1.473 | 0.85 | 0.8186 | 0.4983–1.345 | 0.43 | / | / | / | / | / | / |
| 55,000–64,999$ | 0.8483 | 0.5717–1.259 | 0.41 | 0.7758 | 0.4949–1.216 | 0.27 | / | / | / | / | / | / |
| 65,000–74,999$ | 0.701 | 0.4634–1.060 | 0.093 | 0.6992 | 0.4385–1.115 | 0.13 | / | / | / | / | / | / |
| >74,999$ | 0.8262 | 0.5619–1.215 | 0.33 | 0.714 | 0.4592–1.110 | 0.14 | / | / | / | / | / | / |
| Chemotherapy | ||||||||||||
| no/unknown | reference | reference | reference | reference | ||||||||
| yes | 0.3753 | 0.3065–0.4594 | *** | 0.447 | 0.3525–0.567 | *** | 0.7487 | 0.5273–1.0632 | 0.11 | 0.8836 | 0.5923–1.3181 | 0.54 |
| Radiotherapy | ||||||||||||
| no/unknown | reference | reference | reference | reference | ||||||||
| yes | 0.4247 | 0.3397–0.5308 | *** | 0.4806 | 0.3719–0.621 | *** | 0.6773 | 0.4939–0.9289 | * | 0.8091 | 0.5692–1.1503 | 0.24 |
| Surgery | ||||||||||||
| no/unknown | reference | reference | reference | reference | ||||||||
| yes | 0.1427 | 0.09428–0.216 | *** | 0.1583 | 0.09917–0.2526 | *** | 0.4271 | 0.2609–0.6990 | *** | 0.4491 | 0.2593–0.7777 | ** |
| Bone metastasis | ||||||||||||
| no/unknown | reference | reference | ||||||||||
| yes | 3.568 | 2.892–4.402 | *** | 4.121 | 3.216–5.281 | *** | 2.0779 | 1.4807–2.9161 | *** | 2.5002 | 1.6968–3.6839 | *** |
| Liver metastasis | ||||||||||||
| no/unknown | reference | reference | reference | reference | ||||||||
| yes | 4.443 | 3.358–5.877 | *** | 4.553 | 3.279–6.322 | *** | 2.4709 | 1.5316–3.9863 | *** | 2.604 | 1.5423–4.3963 | *** |
| Lung metastasis | ||||||||||||
| no/unknown | reference | reference | reference | reference | ||||||||
| yes | 4.03 | 3.106–5.229 | *** | 3.432 | 2.483–4.745 | *** | 2.572 | 1.7343–3.8142 | *** | 2.4935 | 1.5642–3.9748 | *** |
| Brain metastasis | ||||||||||||
| no/unknown | reference | reference | reference | reference | ||||||||
| yes | 2.83 | 1.933–4.142 | *** | 2.876 | 1.838- 4.5 | *** | 2.3986 | 1.3387–4.2976 | ** | 2.0765 | 1.0757–4.0083 | * |
* p < 0.05, ** p < 0.01, *** p < 0.001.