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The ITK inhibitor caused a restoration of the Nrf2 signaling in the CNS of sepsis survivor mice. (A) Nrf2 mRNA expression; (B) Nrf2–ARE binding in the cortex; (C) HO-1 mRNA expression; and (D) SOD2 mRNA expression. The values are depicted as the mean ± SEM, n = 6–8/group. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
