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. 2023 May 7;24(9):8401. doi: 10.3390/ijms24098401

Figure 1.

Figure 1

Updated classification of human malignant, bone mass-depositing osteosarcoma considering the latest WHO 2020 guidelines for bone tumors. The picture outlines the location of tumors (note that it can be central or in the surface of the bone, or intramedullary in the bone marrow medulla) and associated molecular and clinical features. Compiled from revision of literature from [34,37,38]. MDM2— human homolog of mouse double minute 2; CDK4—cyclin-dependent kinase 4. Created with BioRender.com (figure created on 13 March 2023).