Table 2.
Prevalence of decreased G6PD enzyme activity with age by different classifications.
| Characteristics | Total n | Decreased G6PD (<7.9 U/g Hb) |
G6PD Deficiency (<30%) |
Intermediate G6PD in Female * (30–80%) |
Class A (<25%, Chronic Non-Spherocytic Hemolytic Anemia) |
Class B (<45%, Triggered Acute Hemolytic Anemia) |
Class U (45–60% or >150%, Uncertain Clinical Significance) |
|---|---|---|---|---|---|---|---|
| 0 to 9 years | 157 (3.0%) | 5 (3.2%) | 3 (1.9%) | 4 (8.0%) | 3 (1.9%) | 2 (1.3%) | 20 (12.7%) |
| 10 to 19 years | 110 (2.1%) | 5 (4.5%) | 1 (0.9%) | 1 (2.3%) | 1 (0.9%) | 0 (0.0%) | 13 (11.8%) |
| 20 to 29 years | 219 (4.2%) | 1 (0.5%) | 1 (0.5%) | 4 (3.1%) | 0 (0.0%) | 1 (0.5%) | 7 (3.2%) |
| 30 to 39 years | 424 (8.2%) | 1 (0.2%) | 1 (0.2%) | 11 (3.5%) | 1 (0.2%) | 0 (0.0%) | 10 (2.4%) |
| 40 to 49 years | 968 (18.6%) | 0 (0.0%) | 0 (0.0%) | 14 (1.9%) | 0 (0.0%) | 1 (0.0%) | 39 (4.0%) |
| 50 to 59 years | 1375 (26.5%) | 3 (0.2%) | 1 (0.1%) | 31 (3.1%) | 1 (0.1%) | 2 (0.0%) | 29 (2.1%) |
| 60 to 69 years | 1208 (23.3%) | 2 (0.2%) | 0 (0.0%) | 30 (4.1%) | 0 (0.0%) | 1 (0.1%) | 36 (3.0%) |
| 70 to 79 years | 508 (9.8%) | 3 (0.6%) | 1 (0.0%) | 5 (1.8%) | 0 (0.0%) | 1 (0.2%) | 15 (3.0%) |
| ≥80 years | 224 (4.3%) | 1 (0.4%) | 2 (0.0%) | 1 (0.7%) | 0 (0.0%) | 1 (0.4%) | 9 (4.0%) |
| Korean | 5111 (98.4%) | 19 (0.4%) | 6 (0.1%) | Not applicable | 5 (0.1%) | 4 (0.1%) | 62 (3.4%) |
| Male | 1693 (33.1%) | 14 (0.8%) | 6 (0.4%) | Not applicable | 5 (0.3%) | 4 (0.2%) | 62 (3.7%) |
| Female | 3418 (66.9%) | 5 (0.1%) | 0 (0.0%) | 100 (2.9%) | 0 (0.0%) | 2 (0.1%) | 114 (3.3%) |
| Non-Korean | 82 (1.6%) | 2 (2.4%) | 1 (1.2%) | Not applicable | 1 (1.2%) | 0 (0.0%) | 2 (2.4%) |
| Male | 29 (35.4%) | 1 (3.4%) | 1 (3.4%) | Not applicable | 1 (3.4%) | 0 (0.0%) | 0 (0.0%) |
| Female | 53 (64.6%) | 1 (1.9%) | 0 (0.0%) | 1 (1.9%) | 0 (0.0%) | 0 (0.0%) | 2 (3.8%) |
| Local clinics | 1792 (34.5%) | 2 (0.1%) | 0 (0.0%) | 37 (2.1%) | 0 (0.0%) | 0 (0.0%) | 22 (1.2%) |
| Hospitals | 1959 (37.7%) | 7 (0.4%) | 2 (0.1%) | 34 (1.7%) | 1 (0.1%) | 4 (0.2%) | 80 (4.1%) |
| University hospitals | 625 (12.0%) | 12 (1.9%) | 5 (0.8%) | 22 (3.5%) | 5 (0.8%) | 2 (0.3%) | 54 (8.6%) |
| Other referral clinical laboratories | 635 (12.2%) | 0 (0.0%) | 0 (0.0%) | 6 (0.9%) | 0 (0.0%) | 0 (0.0%) | 18 (2.8%) |
| Public medical centers | 173 (3.%) | 0 (0.0%) | 0 (0.0%) | 2 (1.2%) | 0 (0.0%) | 0 (0.0%) | 4 (2.2%) |
| Armed forced hospitals | 9 (0.2%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
* Intermediate classification is only applicable for females in the World Health Organization technical consultation series for evaluating diagnostic tests for G6PD activity classification.