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. 2023 May 16;16(5):e009694. doi: 10.1161/CIRCHEARTFAILURE.122.009694

Figure 3.

Figure 3.

Predictive value of multiprotein biomarkers approach for incident heart failure (HF) in addition to routine clinical markers of incident heart failure in the 3 cohorts. Biomarkers retained in multivariable model in each cohort (including NT-proBNP [N-terminal pro-B-type natriuretic peptide]) included the following: ARIC (Atherosclerosis Risk in Communities study; P=55): all significant BMs, except BNP (brain natriuretic peptide)+AXIN1, CASP-3, PDGF subunit A, PDGF subunit B, SRC, STAMPB; FHS (Framingham Heart Study; P=15): all significant BMs, except BNP; HOMAGE (Heart Omics and Ageing cohort; P=109): all significant BMs, except BNP, EPHB4, IL-18BP, OSM, TNF-R1, TNF-R2, TNFRSF14. The clinical model included the following variables: age, sex, smoking, diabetes, history of coronary artery disease, serum creatinine, body mass index, systolic blood pressure, use of antihypertensive medication, heart rate, hypertension, history of atrial fibrillation, and ratio total/high-density lipoprotein cholesterol.