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. 2023 Apr 27;28(9):3781. doi: 10.3390/molecules28093781

Table 2.

Calculated IC50 values and inhibitions percents for thiazoles 1a–10a and 1–5, and oxazoles 11–23.

Comp.
Number		 Structure IC50 (μM)
BChE		 Inhibition
(%) (a) 		Comp.
Number		 Structure IC50 (μM)
BChE		 Inhibition
(%) (a)
1 graphic file with name molecules-28-03781-i001.jpg 107.3 79.1 (500) 11 graphic file with name molecules-28-03781-i002.jpg - 0.9 (188.0)
2 graphic file with name molecules-28-03781-i003.jpg - 46.8 (200) 12 graphic file with name molecules-28-03781-i004.jpg - 40.9 (176.0)
3 graphic file with name molecules-28-03781-i005.jpg 51.1 75.4 (250) 13 graphic file with name molecules-28-03781-i006.jpg 350.7 57.8 (396.8)
4 graphic file with name molecules-28-03781-i007.jpg 41.9 70.8 (200) 14 graphic file with name molecules-28-03781-i008.jpg 154.7 63.3 (173.6)
5 graphic file with name molecules-28-03781-i009.jpg - 24.9 (250) 15 graphic file with name molecules-28-03781-i010.jpg 44.4 98.3 (368.6)
cis-1a graphic file with name molecules-28-03781-i011.jpg - 36.4 (500) 16 graphic file with name molecules-28-03781-i012.jpg 137.4 64.9 (201.7)
trans-1a graphic file with name molecules-28-03781-i013.jpg 181.4 64.0 (500) 17 graphic file with name molecules-28-03781-i014.jpg - 16.8 (159.5)
cis-2a graphic file with name molecules-28-03781-i015.jpg - 45.5 (250) 18 graphic file with name molecules-28-03781-i016.jpg - 38.0 (273.6)
trans-2a graphic file with name molecules-28-03781-i017.jpg - 45.8 (250) 19 graphic file with name molecules-28-03781-i018.jpg 170.2 81.9 (405.2)
trans-3a graphic file with name molecules-28-03781-i019.jpg - 10.0 (250) 20 graphic file with name molecules-28-03781-i020.jpg 183.9 82.2 (364.2)
5a graphic file with name molecules-28-03781-i021.jpg - 30.6 (250) 21 graphic file with name molecules-28-03781-i022.jpg - 32.6 (312.3)
trans-8a graphic file with name molecules-28-03781-i023.jpg 25.2 80.5 (250) 22 graphic file with name molecules-28-03781-i024.jpg 127.7 69.9 (315.8)
trans-9a graphic file with name molecules-28-03781-i025.jpg - (b) 47.7 (100) 23 graphic file with name molecules-28-03781-i026.jpg - 20.6 (297.5)
trans-10a graphic file with name molecules-28-03781-i027.jpg - (b) 25.3 (100) Huperzine A 53.4

(a) Concentrations in μM are given in brackets for the maximal effect measured. (b) For compounds trans-9a and trans-10a, it was impossible to determine the IC50 values due to the coloration of the samples.