Working Principle |
The printer utilizes pneumatic or mechanical driving based on predesigned commands to move the nozzle and distribute bioink according to the desired shape. |
The bioink is expelled from the nozzle in droplet form by adjusting the pressure, like a conventional 2D desktop inkjet printer. |
Using laser scanning or projection to crosslink photopolymerizable hydrogels containing cells at specific locations, solidification occurs, forming a robust structure. |
Advantages |
It can handle high-viscosity bioink, allowing for linear printing of high-viscosity materials. |
This technique offers simplicity in operation, affordability, speed, and remarkable material adaptability. |
It offers high processing precision, non-contact processing, minimal environmental restrictions, adaptability, and operability. |
Drawbacks |
The generation of potential shear stress within the nozzle has the potential to cause cell damage and reduce cell viability. |
It is easy to generate spattering from the expelled fluid, which leads to waste, and its accuracy is roughly one-tenth that of extrusion printing. |
This method may lead to phototoxicity, which can hinder cell growth. |
Print speed |
Slow |
Fast |
Fast |
Printer cost |
Medium |
Low |
High |
Cell density |
Medium, 106–107
|
Low, 104–106
|
Medium, 107
|
Ref. |
[17,21,22,23] |
[22,25,26,28] |
[29,30,33] |