To sum up

Pros

The loading of AgNPs with flavonoids induces the biocompatibility of nanoparti-cles and reduces their toxicity. The connections of silver nanoparticles with particular flavonoids revealed a wide spectrum of potential antioxidant, antibacterial, antifungal, antiparasitic, antivi-ral, and anticancer properties.

Cons

Functionalization of nanoparticles with hesperidin was found to cause stability problems, as the zeta potentials of the nanoparticles were closer to neutral [43]. Some of the nanoparticles reveal strong positive zeta potentials, which may cause toxicity [55]. The nanoparticles discussed in the presented studies were of relatively small size, <20 nm, which is a poor indicator for biocompatibility [56].