Table 1.
Categories of Outcomes | Outcomes Included | |
---|---|---|
Primary outcomes | Mortality | All-cause mortality; BC mortality; non-BC mortality. |
BC recurrence and/or newly diagnosed cancer progression |
e.g., local recurrence; metastasis. |
|
Quality of life | Measured by generic or cancer-specific validated scales, (e.g., Functional Assessment of Cancer Therapy—Breast Cancer). |
|
Secondary outcomes | Health-related parameters | Biochemical parameters, (e.g., blood glucose and blood lipids, including total cholesterol, low-density lipoproteins, high-density lipoproteins, triglycerides). |
Anthropometric measurements, (e.g., body-mass index, waist circumference, body weight). | ||
Incidence of long-term/late-effect BC treatments |
Osteoporosis/osteopenia/fracture; obesity/cardiovascular disease/stroke/diabetes; endometrial cancer/other secondary cancer (primary cancer); cognitive impairment; mortality from cancer treatments. |
|
Adverse events |
BC: breast cancer.