Risk of bias [18,26,27,28,29,30,31,32,33,34,35,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51]. * D1: Randomization process; D2: Deviations from the intended interventions; D3: Missing outcome data; D4: Measurement of outcome; D5: Selection of the reported result.