Fig. 6. The somatic proto-oncogene editing method can better reveal Wnt signaling protein features than the lentivirus-mediated oncogene delivery method.

(A) Bar graph showing differential RPPA protein features detected by RPPA (P < 0.05 cutoff by t test). The dashed line is the expected level of differences caused by random chance due to multiple testing. (B) Heatmap showing RPPA protein features. (C) Venn diagram showing differential protein features from comparing tumors on the MMTV-Wnt1 versus WT background. The edited genetic drivers are indicated at the top.