TABLE 2.
Bacterial densities in vegetations and spleens of rats that developed experimental endocarditis after challenge with inoculum sizes equal to the 60% infections dose of the parent strain Newman
| S. aureus strain | Clf phenotype | Median (25%–75%) bacterial density in infected tissues (CFU/g)
|
|
|---|---|---|---|
| Vegetations | Spleens | ||
| Newman | ClfA+ ClfB+ | 7.44 (5.34–8.10) | 3.51 (2.91–4.02) |
| DU5852 | ClfA− ClfB+ | 6.93 (6.31–7.90) | 2.80 (2.63–4.63) |
| DU5943 | ClfA+ ClfB− | 7.90 (7.37–8.21) | 3.66 (2.61–4.62) |
| DU5944 | ClfA− ClfB− | 7.72 (7.40–7.96) | 3.25 (2.62–4.45) |
| DU5943(pCU1-clfB+) | ClfA+ ClfB+ (complemented) | 7.26 (5.09–7.86) | 2.96 (2.49–4.61) |
| DU5944(pCU1-clfB+) | ClfA− ClfB+ (complemented) | 6.58 (4.62–7.40) | 3.46 (3.12–4.61) |