Table 2.
Features and comparison between High anti-tTG IgA titer (HT) and Low anti-tTG IgA titer (LT) patients at the time of GFD follow-up.
| HT Patients with Ab > 10 ULN n = 105 (48.6%) | LT Patients with Ab < 10 ULN n = 111 (51.4%) | p Value | |
|---|---|---|---|
| Females | 76.2% | 65.8% | 0.101 |
| Median months of GFD (range) | 14 (12–36) | 14 (12–36) | 0.435 |
| Adequate GFD | 95% | 91.8% | 0.414 |
| Median BMI kg/m2 (range) | 22.4 (16.3–32.8) | 23 (20.5–36.6) | 0.284 |
| Underweight (BMI < 18 kg/m2) | 5.3% | 3.9% | 0.739 |
|
GI symptoms Total pts with GI symptoms Nausea/Vomit Heartburn Regurgitation Dysphagia Postprandial fullness/early satiety Abdominal pain Abdominal bloating Constipation Diarrhoea |
24.3% 1% 5.8% 2.9% 0 3.9% 9.6% 11.6% 5.8% 4.8% |
38.2% 3.7% 9.2% 5.6% 1.8% 7.3% 18.3% 21.1% 10.1% 8.2% |
0.038 0.370 0.439 0.499 0.376 0.047 0.067 0.315 0.410 |
| Antibodies positivity | 34.3% | 14.4% | 0.001 |
|
Signs of malabsorption Total pts with signs of malabsorption Anaemia Hypoferritinaemia Hypocholesterolaemia Hypotriglyceridaemia |
29.1% 13.7% 28.4% 2% 11.6% |
33.9% 11.2% 28.1% 3.9% 8% |
0.464 1 1 0.684 0.472 |
|
Hystological control
Marsh III (atrophic disease) Marsh 0 score |
79% 33.3% 54.7% |
89.1% 24.2% 58.6% |
0.060 0.191 0.654 |
Legend: ULN: upper the normal limit; GFD: Gluten-free diet; BMI: Body Mass Index; GI: Gastrointestinal.