Table 2. Univariate Cox regression for influence of cerebrospinal fluid (CSF) metabolites on 60-day mortality.

Metabolites	HR*	95% CI*	p-value	FDR†
Tryptophan	1.16	1.10, 1.24	<0.001	<0.001
Kynurenine	1.00	0.93, 1.07	>0.9	>0.9
Kynurenic acid	1.00	0.93, 1.07	0.9	>0.9
3-Hydroxyanthranilic acid	1.01	0.97, 1.05	0.6	0.9
Xanthurenic acid	0.95	0.90, 1.00	0.05	0.2
Quinolinic acid	0.92	0.85, 1.00	0.038	0.2
Niacinamide	1.03	0.95, 1.11	0.5	0.8
3-Indoleacetic acid	1.11	0.96, 1.29	0.2	0.4
N-Acetylserotonin	1.01	0.94, 1.09	0.7	0.9
5-Methoxytryptophol	1.11	0.93, 1.32	0.3	0.5

Baseline cerebrospinal fluid (CSF) metabolites were measured in 1069 TBM patients. Cox regression models were stratified by cohort and adjusted by sex, age, and HIV status. Hazard ratio (HR) was calculated per twofold increase in metabolite concentration. Bold: False Discovery Rate (FDR) < 0.05.

^*HR = hazard ratio, CI = confidence interval.

^†FDR = false discovery rate; Benjamini and Hochberg correction for multiple testing.