Table 3. Univariate Cox regression for influencen of baseline cerebrospinal fluid (CSF) metabolites on early and late mortality.
| Metabolite | Early mortality (days 0–14) | Late mortality (days 14–180) | ||||||
|---|---|---|---|---|---|---|---|---|
| HR* | 95% CI* | p-value | FDR† | HR* | 95% CI* | p-value | FDR† | |
| Tryptophan | 1.14 | 1.06, 1.23 | <0.001 | 0.005 | 1.17 | 1.08, 1.26 | <0.001 | <0.001 |
| Kynurenine | 1.03 | 0.95, 1.13 | 0.4 | 0.6 | 1 | 0.91, 1.10 | >0.9 | >0.9 |
| Kynurenic acid | 1.05 | 0.96, 1.14 | 0.3 | 0.5 | 0.95 | 0.86, 1.04 | 0.3 | 0.5 |
| 3-Hydroxyanthranilic acid | 1.02 | 0.97, 1.06 | 0.5 | 0.6 | 1.01 | 0.96, 1.06 | 0.6 | 0.7 |
| Xanthurenic acid | 0.96 | 0.90, 1.03 | 0.2 | 0.5 | 0.96 | 0.89, 1.04 | 0.3 | 0.5 |
| Quinolinic acid | 0.89 | 0.81, 0.98 | 0.02 | 0.1 | 0.9 | 0.81, 1.00 | 0.052 | 0.2 |
| Niacinamide | 1.02 | 0.92, 1.12 | 0.7 | 0.7 | 1.05 | 0.95, 1.16 | 0.3 | 0.5 |
| 3-Indoleacetic acid | 1.1 | 0.92, 1.32 | 0.3 | 0.5 | 1.18 | 0.97, 1.43 | 0.093 | 0.2 |
| N-Acetylserotonin | 1.05 | 0.96, 1.14 | 0.3 | 0.5 | 0.96 | 0.88, 1.06 | 0.4 | 0.5 |
| 5-Methoxytryptophol | 1.09 | 0.87, 1.35 | 0.5 | 0.6 | 1.29 | 1.04, 1.59 | 0.02 | 0.1 |
Baseline cerebrospinal fluid (CSF) metabolites were measured in 1069 TBM patients. Cox regression models were stratified by sites and adjusted by age, sex, and GCS. Bold: False Discovery Rate (FDR) < 0.05.
*
HR = hazard ratio, CI = confidence interval.
†
Benjamini and Hochberg correction for multiple testing.