Table 4. Univariate Cox regression for influence of baseline plasma metabolites on 60-day mortality.

Metabolite	HR*	95% CI*	p-value	FDR†
Tryptophan	0.8	0.56, 1.16	0.2	0.4
Kynurenine	1.54	1.22, 1.93	<0.001	0.002
Kynurenic acid	1.2	1.01, 1.43	0.036	0.2
3-Hydroxyanthranilic acid	1.13	1.00, 1.28	0.045	0.2
Xanthurenic acid	1.11	0.98, 1.25	0.1	0.3
Quinolinic acid	0.99	0.88, 1.12	0.9	0.9
Niacinamide	0.92	0.79, 1.07	0.3	0.4
3-Indoleacetic acid	1.04	0.97, 1.12	0.3	0.4
N-Acetylserotonin	1.05	0.91, 1.22	0.5	0.6
5-Methoxytryptophol	1.04	0.85, 1.28	0.7	0.8

Baseline plasma tryptophan metabolites were measured in a subset 300 patients. Cox regression models were stratified by sites and adjusted by age, sex, and GCS. Bold: False Discovery Rate (FDR) < 0.05.

^*HR = hazard ratio, CI = confidence interval.

^†Benjamini and Hochberg correction for multiple testing.