Appendix 1—table 9. Comparison of brain-age deltas for the different amyloid-β, AT and APOE status.

	Mean square	F	P-Value
CU
Amyloid-β status	35.787	39.369	<0.001
AT Stage	21.550	11.626	<0.001
APOE status	16.218	5.862	<0.001
MCI
Amyloid-β status	47.166	52.412	<0.001
AT Stage	50.064	27.701	<0.001
APOE status	10.049	3.425	0.017

Brain-age deltas for pooled CU and MCI individuals were compared for the different amyloid-β, AT and APOE status with ANCOVA models adjusted by age and sex.

Amyloid-β status was defined by CSF (ALFA+, ADNI and EPAD) or amyloid PET (OASIS).

Significant values (P<0.05) are marked in bold.

APOE, apolipoprotein E; ANCOVA, analysis of covariance.