Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 6;55(5):841–851. doi: 10.1038/s41588-023-01366-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 7 — (a) Heatmap of fold-changes versus full (100) SOX9 dosage for all all genes for which SOX9 dosage explains a significant (5% FDR) amount of variance (likelihood ratio test), clustered by row based on Kendall distance (b) Examples of genes upregulated in response to SOX9 depletion with buffered (left) or sensitive (right) responses. Black and blue lines represent Hill and linear fits, respectively (c) Principal component analysis of RNA-seq counts per million (CPM) across all SOX9-tagged and WT CNCC samples. Shapes indicate the dTAGV-1 concentration treated for 48 h. Colors indicate the combination of hESC line from which CNCCs were derived and differentiation batch (S9c1/2 = SOX9-tagged clone1/2). Arrow indicates the SOX9 dosage effect.