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. 2023 Apr 6;55(5):841–851. doi: 10.1038/s41588-023-01366-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, ED₅₀ of SOX9-downregulated genes stratified by presence in the ‘Cartilage development’ Gene Ontology (GO) category (x axis), and expression change in chondrocytes compared to CNCCs (color, data from ref. ²⁹). n of groups from left to right: 157, 269, 241, 6, 4, 11. Points and error bars represent median and 95% confidence intervals as computed by 200 bootstraps (see Methods). b, Examples of known pro-chondrogenic genes that are moderately or highly sensitive to SOX9 dosage. c, Schematic of approach to titrate SOX9 dosage during 21-day chondrogenic differentiation. d, Sulfated glycosaminoglycan (sGAG, representative of mature cartilage) content at day 21 of chondrogenesis as a function of SOX9 dosage as estimated in Extended Data Fig. 9b. Black curve represents Hill equation fit. e, Median dosage curves based on fitted ED₅₀ and Hill exponents for all REs and genes, pro-chondrogenic genes (purple, labeled group in a) and sGAG content (from d).