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. 2023 Apr 6;55(5):807–819. doi: 10.1038/s41588-023-01355-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Logistic regression analysis summary in the SU2C-MARK cohort between TI signatures and binned response category (PR/CR versus SD/PD). The dedifferentiated (TI-1) signature showed a significant association with response (q < 0.1, logistic regression with Benjamini–Hochberg adjustment). b, Kernel density estimate plot of the association between the activities of the dedifferentiated (TI-1) signature and the previously identified immune-activated (M-2) signature. c, Response rate in the SU2C-MARK cohort binned by expression of TI-1 and M-2 signatures. Patients with both high TI-1 and high M-2 show the highest response rate.