Table 2.
Mendelian randomization of basal metabolic rate (Neale Lab) on survival to old age (Deelen et al.). CI: confidence interval; GV: genetic variant; IVW: inverse-variance weighting; LL: lower limit; MR: Mendelian randomization; MR-RAPS: Mendelian Randomization Robust Adjusted Profile Score; MR-PRESSO: Mendelian Randomization Pleiotropy Residual Sum and Outlier; SE: standard error; UL: upper limit; WM: weighted median.
| Exposure | Outcome | Selection of GVs | No. of GVs | MR method | Beta | Odds ratio | p-value | Cochran's Q | MR-Egger | Outlier detected | Sex difference | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trait | Sex | Trait | Sex | Estimate | SE | 95% CI LL | 95% CI UL | Estimate | 95% CI LL | 95% CI UL | Statistic | p-value | Intercept | Intercept p-value | I2GX | by MR-PRESSO | z statistic | p-value | ||||
| Men | ||||||||||||||||||||||
| Basal metabolic rate | Men | Survival to 99th percentile of age | Overall | All | 202 | IVW (random) | −0.087 | 0.095 | −0.275 | 0.100 | 0.916 | 0.760 | 1.105 | 0.359 | 259.518 | 0.003 | – | – | – | – | 0.420 | 0.674 |
| All | 202 | WM | −0.217 | 0.136 | −0.484 | 0.050 | 0.805 | 0.617 | 1.051 | 0.111 | – | – | – | – | – | – | 1.098 | 0.272 | ||||
| All | 202 | MR-Egger | −0.339 | 0.280 | −0.888 | 0.210 | 0.713 | 0.412 | 1.234 | 0.226 | 258.342 | 0.003 | 0.008 | 0.340 | 0.838 | – | 0.010 | 0.992 | ||||
| All | 202 | MR-RAPS | −0.089 | 0.085 | −0.256 | 0.078 | 0.914 | 0.774 | 1.081 | 0.294 | – | – | – | – | – | – | 0.474 | 0.636 | ||||
| All | 201 | MR-PRESSO (corrected) | −0.062 | 0.093 | −0.245 | 0.122 | 0.940 | 0.783 | 1.130 | 0.510 | – | – | – | – | – | rs768023 | 0.242 | 0.809 | ||||
| Exclusion of potentially confounded GVs | 186 | IVW (random) | −0.042 | 0.102 | −0.241 | 0.158 | 0.959 | 0.786 | 1.172 | 0.684 | 231.722 | 0.011 | – | – | – | – | 0.785 | 0.433 | ||||
| Exclusion of potentially confounded GVs | 186 | WM | −0.185 | 0.145 | −0.468 | 0.099 | 0.831 | 0.626 | 1.104 | 0.202 | – | – | – | – | – | – | 1.622 | 0.105 | ||||
| Exclusion of potentially confounded GVs | 186 | MR-Egger | −0.126 | 0.315 | −0.744 | 0.491 | 0.881 | 0.475 | 1.634 | 0.689 | 231.621 | 0.010 | 0.003 | 0.776 | 0.791 | – | 0.461 | 0.645 | ||||
| Exclusion of potentially confounded GVs | 186 | MR-RAPS | −0.042 | 0.093 | −0.224 | 0.139 | 0.958 | 0.799 | 1.149 | 0.646 | – | – | – | – | – | – | 0.864 | 0.388 | ||||
| Exclusion of potentially confounded GVs | 185 | MR-PRESSO (corrected) | −0.011 | 0.099 | −0.206 | 0.185 | 0.989 | 0.814 | 1.203 | 0.915 | – | – | – | – | – | rs768023 | 0.755 | 0.450 | ||||
| Basal metabolic rate | Men | Survival to 90th percentile of age | Overall | All | 204 | IVW (random) | −0.098 | 0.063 | −0.221 | 0.026 | 0.907 | 0.801 | 1.026 | 0.120 | 288.099 | 7.92E−05 | – | – | – | – | 0.381 | 0.704 |
| All | 204 | WM | −0.048 | 0.086 | −0.217 | 0.122 | 0.953 | 0.805 | 1.129 | 0.581 | - | - | - | - | - | - | 0.071 | 0.943 | ||||
| All | 204 | MR-Egger | −0.313 | 0.179 | −0.665 | 0.039 | 0.731 | 0.514 | 1.040 | 0.081 | 285.783 | 9.46E−05 | 0.007 | 0.201 | 0.832 | - | 0.422 | 0.673 | ||||
| All | 204 | MR-RAPS | −0.100 | 0.054 | −0.205 | 0.005 | 0.905 | 0.814 | 1.005 | 0.061 | – | – | – | – | – | – | 0.442 | 0.659 | ||||
| All | 203 | MR-PRESSO (corrected) | −0.082 | 0.062 | −0.203 | 0.040 | 0.921 | 0.816 | 1.040 | 0.186 | – | – | – | – | – | rs768023 | 0.622 | 0.534 | ||||
| Exclusion of potentially confounded GVs | 188 | IVW (random) | −0.104 | 0.068 | −0.236 | 0.029 | 0.902 | 0.789 | 1.030 | 0.126 | 262.112 | 0.0002 | – | – | – | – | 0.793 | 0.428 | ||||
| Exclusion of potentially confounded GVs | 188 | WM | −0.010 | 0.092 | −0.189 | 0.170 | 0.991 | 0.828 | 1.185 | 0.917 | – | – | – | – | – | – | 0.491 | 0.623 | ||||
| Exclusion of potentially confounded GVs | 188 | MR-Egger | −0.305 | 0.201 | −0.699 | 0.089 | 0.737 | 0.497 | 1.093 | 0.129 | 260.522 | 0.0003 | 0.006 | 0.287 | 0.783 | – | 1.035 | 0.301 | ||||
| Exclusion of potentially confounded GVs | 188 | MR-RAPS | −0.106 | 0.058 | −0.220 | 0.007 | 0.899 | 0.802 | 1.008 | 0.067 | – | – | – | – | – | – | 0.934 | 0.350 | ||||
| Exclusion of potentially confounded GVs | 187 | MR-PRESSO (corrected) | −0.085 | 0.066 | −0.215 | 0.046 | 0.919 | 0.806 | 1.047 | 0.201 | – | – | – | – | – | rs768023 | 0.796 | 0.426 | ||||
| Women | ||||||||||||||||||||||
| Basal metabolic rate | Women | Survival to 99th percentile of age | Overall | All | 202 | IVW (random) | −0.029 | 0.100 | −0.225 | 0.167 | 0.971 | 0.798 | 1.182 | 0.770 | 249.285 | 0.012 | – | – | – | – | ||
| All | 202 | WM | −0.0003 | 0.143 | −0.280 | 0.280 | 0.9997 | 0.756 | 1.322 | 0.998 | – | – | – | – | – | – | ||||||
| All | 202 | MR-Egger | −0.335 | 0.293 | −0.909 | 0.238 | 0.715 | 0.403 | 1.269 | 0.252 | 247.751 | 0.012 | 0.009 | 0.266 | 0.867 | – | ||||||
| All | 202 | MR-RAPS | −0.030 | 0.091 | −0.209 | 0.149 | 0.971 | 0.812 | 1.161 | 0.743 | – | – | – | – | – | – | ||||||
| All | 202 | MR-PRESSO* | −0.029 | 0.100 | −0.227 | 0.168 | 0.971 | 0.797 | 1.183 | 0.770 | – | – | – | – | – | – | ||||||
| Exclusion of potentially confounded GVs | 183 | IVW (random) | 0.074 | 0.107 | −0.136 | 0.284 | 1.077 | 0.873 | 1.329 | 0.490 | 218.214 | 0.034 | – | – | – | – | ||||||
| Exclusion of potentially confounded GVs | 183 | WM | 0.157 | 0.153 | −0.143 | 0.457 | 1.170 | 0.867 | 1.579 | 0.305 | – | – | – | – | – | – | ||||||
| Exclusion of potentially confounded GVs | 183 | MR-Egger | 0.087 | 0.338 | −0.575 | 0.749 | 1.091 | 0.563 | 2.114 | 0.797 | 218.212 | 0.031 | –0.0004 | 0.968 | 0.836 | – | ||||||
| Exclusion of potentially confounded GVs | 183 | MR-RAPS | 0.076 | 0.100 | −0.120 | 0.271 | 1.079 | 0.887 | 1.311 | 0.447 | – | – | – | – | – | – | ||||||
| Exclusion of potentially confounded GVs | 182 | MR-PRESSO (corrected) | 0.098 | 0.105 | −0.109 | 0.305 | 1.103 | 0.896 | 1.356 | 0.353 | – | – | – | – | – | rs599004 | ||||||
| Basal metabolic rate | Women | Survival to 90th percentile of age | Overall | All | 203 | IVW (random) | −0.063 | 0.067 | −0.194 | 0.067 | 0.939 | 0.824 | 1.070 | 0.343 | 277.242 | 0.0003 | – | – | – | – | ||
| All | 203 | WM | −0.057 | 0.093 | −0.239 | 0.126 | 0.945 | 0.787 | 1.134 | 0.542 | – | – | – | – | – | – | ||||||
| All | 203 | MR-Egger | −0.202 | 0.193 | −0.580 | 0.177 | 0.817 | 0.560 | 1.194 | 0.297 | 276.441 | 0.0003 | 0.004 | 0.446 | 0.851 | – | ||||||
| All | 203 | MR-RAPS | −0.065 | 0.058 | −0.178 | 0.048 | 0.937 | 0.837 | 1.050 | 0.262 | – | – | – | – | – | – | ||||||
| All | 201 | MR-PRESSO (corrected) | −0.027 | 0.063 | −0.152 | 0.098 | 0.974 | 0.859 | 1.103 | 0.673 | – | – | – | – | – | rs3800228, rs599004 | ||||||
| Exclusion of potentially confounded GVs | 184 | IVW (random) | −0.026 | 0.071 | −0.164 | 0.113 | 0.974 | 0.848 | 1.119 | 0.714 | 237.752 | 0.004 | – | – | – | – | ||||||
| Exclusion of potentially confounded GVs | 184 | WM | 0.056 | 0.098 | −0.136 | 0.248 | 1.058 | 0.873 | 1.281 | 0.568 | – | – | – | – | – | – | ||||||
| Exclusion of potentially confounded GVs | 184 | MR-Egger | 0.002 | 0.218 | −0.426 | 0.430 | 1.002 | 0.653 | 1.537 | 0.994 | 237.728 | 0.003 | –0.0008 | 0.894 | 0.812 | – | ||||||
| Exclusion of potentially confounded GVs | 184 | MR-RAPS | −0.026 | 0.063 | −0.150 | 0.097 | 0.974 | 0.861 | 1.102 | 0.674 | – | – | – | – | – | – | ||||||
| Exclusion of potentially confounded GVs | 183 | MR-PRESSO (corrected) | −0.009 | 0.069 | −0.145 | 0.126 | 0.991 | 0.865 | 1.135 | 0.895 | – | – | – | – | – | rs599004 | ||||||