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. 2023 May 12;14(5):321. doi: 10.1038/s41419-023-05843-8

Fig. 1. Clinical-grade hUC-MSCs improved muscle strength and restored skeletal muscle morphology in SAMP8 mice.

Fig. 1

A Illustrated in schematic form is the chronological sequence used for hUC-MSCs or PBS treatment, behavioral tests, immunostaining, western blotting and others. B, C Evaluation of muscle strength was performed by measuring gripping (PR1&PBS = 0.0018; PMSC & PBS = 0.0012) and anti-fatigue (PR1 & PBS = 0.0001; PMSC & PBS = 0.0001) capacities. The time of Latency to fall in the Rota Rod system was used to reflect the muscle endurance, and gripping test was used to show the grip strength of SAMP8 mice (n = 6–7 per group). D The representative cross-sections of gastrocnemius muscle were stained with H&E to observe better the morphology of muscle cells in R1, P8-PBS, and P8-MSC groups (scale bar = 100 μm). E, F Quantitative analysis of muscle fiber cross-sectional area (PR1 & PBS < 0.0001; PMSC & PBS < 0.0001) (μm2) and muscle fiber diameter (PR1 & PBS = 0.0029; PMSC & PBS < 0.0001) (μm2) in SAMP8 mice. (n = 8 or 10 views per group from 5–6 male mice; all data shown as mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001).