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. 2023 May 12;14:2745. doi: 10.1038/s41467-023-38220-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The transcriptional changes of selected chaperones. Normalized counts of transcription are plotted. control: the samples without 2H treatment. The gene names are labeled under each plot. Source data are provided as a Source Data file. Data are presented as mean values + /- SEM (n = 3 independent experiments). Individual data points are shown in red. b The overall changes of gene expression upon 2H treatment. Fold of change was calculated using the ratios of normalized counts of the 2H-treated SC5314 samples over the non-treatment controls. DEseq2 was used to identify differentially expressed genes through a Wald test, employing a two-tailed p-value approach (adjusted using the Benjamini-Hochberg method). c The top pathways in SC5314 influenced by 2H treatment. The scales of gene ratio (GeneRatio) and adjusted P-value (p.adjust) are listed on the right. Up-regulated expression (up_exp) and down-regulated expression (down_exp) are plotted. A one-sided version of Fisher’s exact test was performed, and the p-value was adjusted using the Benjamini-Hochberg method.