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. 2023 May 12;14:2744. doi: 10.1038/s41467-023-38271-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A map of TIME eQTL biological functions, immune functions and cancer associations for 15 genes implicated as modifiers of immune checkpoint blockade response. Innate immune function indicates that TIME eQTLs are also DICE eQTLs for macrophages, monocytes or dendritic cells. Adaptive immune function indicates that TIME eQTLs are also DICE eQTLs for CD8+ T cells, CD4+ T cells, or B cells. Risk indicates whether a gene was also implicated in PRS models. Survival indicates whether a gene was also implicated in PSS models. Asterisks indicate that a small molecule inhibitor has been reported for a gene. Source data are provided in the Source Data file.