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. 2023 May 12;13:7757. doi: 10.1038/s41598-023-34781-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Linear regression analyses indicated a significant interaction between a clump comprising 29 SNPs in the P2RX7 gene and exposure to childhood adversities on the severity of current anxiety symptoms, with the minor or effect alleles as a protective allele. For visualization purposes we show this effect for the top/index SNP rs67881993, with a protective effect for the minor T allele. Data on all P2RX7 SNPs in the original NewMood database, including quality control and regression results in interaction with CHA for dominant models are shown in Supplementary Table S1.

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