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. 2023 May 12;14(5):322. doi: 10.1038/s41419-023-05837-6

Fig. 6. PRMT2 promotes RCC tumorigenesis and metastasis by increasing WNT5A expression in vivo.

Fig. 6

A, B ACHN-shCtrl cells or ACHN-shPRMT2 cells were subcutaneously injected into the flanks of BALB/c nude mice. n = 8 for each group. The subcutaneous tumors were weighed up. C IHC detected PRMT2, WNT5A, Ki-67, and Cyclin-D1 in subcutaneous tumors. D, E The same number of ACHN-shCtrl cells or ACHN-shPRMT2 cells were injected into BALB/c nude mice through the tail vein. n = 6 for each group. Representative lung images were shown when mice were sacrificed after 8 weeks (D), the red arrows denote the metastatic nodules, and lung metastatic nodules were examined macroscopically (E). F Hematoxylin/Eosin-stained (H&E) lung sections were shown. G Representative images of the IHC staining of PRMT2 and WNT5A in lung metastasis sections. Data are presented as the mean ± SD. **P < 0.01; ***P < 0.001.