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. 2023 Feb 10;48(7):1981–1996. doi: 10.1007/s11064-023-03887-y

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Fig. 4 — Protective mechanisms of H₂S in AD. The neuroprotective effects of H₂S in AD are associated with inhibition of anti-inflammatory cascade via reduction of TNF-β and IL-6 levels. Moreover, H₂S has been linked to reduction of size of β-amyloid plaques and reduction in hyperphosphorylation of Tau. H₂S has been observed to reduce levels of mitochondrial reactive oxygen species (ROS) leading to inhibition of apoptosis via caspase 3. H₂S may also maintain the integrity of mitochondrial DNA whilst it may also regulate GSK3β protein functions via S-sulfhydration (persulfidation)