Fig. 5.

Decision curve analysis (DCA) of the four models. The net benefit is calculated by subtracting the proportion of false-positive patients from the proportion of true-positive patients, weighted by the relative harm of a false-positive result and a false-negative result. The two extreme strategies “treat all” and “treat none” are displayed as a reference. A decision model shows a clinical benefit if the decision curve shows a larger net benefit than both reference strategies