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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Pain. 2022 Nov 29;164(6):e274–e285. doi: 10.1097/j.pain.0000000000002834

Figure 3: CIPN increases lipid raft content and TRPV1 localization to lipid rafts in DRG neurons.

Figure 3:

A-B. Whole DRGs were collected from male mice treated with to i.p. paclitaxel (2 injections of 8 mg/kg), followed by i.t. saline (5μl) or AIBP (0.5 μg/ 5 μl), as in Fig. 2A (but in a separate experiment), stained for TRPV1 (red), and lipid rafts (CTxB; green), and subjected to a clearing protocol as described in Methods. Representative images (A) and quantitative data (B). Scale bar, 20 μm. Mean±SEM (n=4 per group); ****, p<0.0001 (one-way ANOVA).