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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Pain. 2022 Nov 29;164(6):e274–e285. doi: 10.1097/j.pain.0000000000002834

Figure 6: Paclitaxel increases TRPV1 activity in vitro: inhibition by AIBP.

Figure 6:

Calcium influx in response to capsaicin was recorded from DRG cultured neurons incubated for 2 hours with paclitaxel (3 μM), AIBP 0.1 μg/mL, or paclitaxel+AIBP, and then loaded with Fluo-4. Neurons were buffered for 2 min, then stimulated for 15 sec with capsaicin (0.5 μM). See Supplemental Figure 3 for subsequent KCl stimulation. The maximal ΔF/F0 was quantified for the capsaicin response. Five to nine neuronal culture dishes from 4 different naïve wild type mice were stimulated in vitro. Total number of recorded cells per treatments: control(buffer)=19, paclitaxel=23, AIBP=15, and paclitaxel+AIBP=20. Mean±SEM; **, p<0.01. ***, p<0.001 (one-way ANOVA).