Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Local and systemic injection of 3-oxa-PD1 reduces acute, persistent, and chronic itch in mouse models. 3-oxa-PD1 inhibits central sensitization in spinal cord neurons by modulation of both excitatory and inhibitory synaptic transmission in CTCL mice. Furthermore, 3-oxa-PD1 can suppress spinal cord production and astrocyte release of LCN2, an astrocyte-produced itch mediator.
