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Differential expression analysis of ER+ patients above the 75th percentile of RET and GDNF expression (high RET/GDNF) relative to all other ER+ patients demonstrated by a (A) volcano plot of all genes with significantly upregulated and downregulated genes having L2FC > 1 and < −1 respectively along with FDR < 0.05 and (B) heatmap of top 40 significant upregulated and downregulated differentially expressed genes defining high RET/GDNF ER+ tumors.
